Basic Information
| LncRNA/CircRNA Name | circRNF13 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Lung Adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, RIP, RNAi, other |
| Sample | LAC tissues and cell lines (A549, H1299, H2228, pc9, H1975 and H827) |
| Expression Pattern | down-regulated |
| Function Description | The expression level of circRNF13 was significantly negatively correlated with TNM staging and lymph node metastasis. In vitro experiments indicated that circRNF13 repressed the invasion and metastasis of lung adenocarcinoma cell lines. Cell fraction analyses and fluorescence in situ hybridization detected that circRNF13 was mostly located in the cytoplasm. Bioinformatic analyses and RIP experiments revealed that circRNF13 could interact with Ago2, an RNA binding protein, and could function as sponge for miR-93-5p. Our data suggest that circRNF13 represents a potential novel biomarker and a therapeutic target of lung adenocarcinoma. |
| Pubmed ID | 29704631 |
| Year | 2018 |
| Title | CircRNF13 Regulates the Invasion and Metastasis in Lung Adenocarcinoma by Targeting miR-93-5p |
External Links
| Links for circRNF13 | GenBank HGNC NONCODE |
| Links for Lung Adenocarcinoma | OMIM COSMIC |