Basic Information
| LncRNA/CircRNA Name | circSHKBP1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, luciferase reporter assay, RIP, other |
| Sample | glioblastoma tissues and cell line (U87MG, HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | The expressions of miR-379/miR-544a were downregulated in GECs, and circ-SHKBP1 functionally targeted miR-544a/miR-379 in an RNA-induced silencing complex (RISC) manner. Dual-luciferase reporter assay demonstrated that forkhead box P1/P2 (FOXP1/FOXP2) were targets of miR-544a/miR-379. The expressions of FOXP1/FOXP2 were upregulated in GECs, and silencing of FOXP1/FOXP2 inhibited the viability, migration, and tube formation of GECs. Meanwhile, FOXP1/FOXP2 promoted angiogenic factor with G patch and FHA domains 1 (AGGF1) expression at the transcriptional level. Furthermore, knockdown of AGGF1 suppressed the viability, migration, and tube formation of GECs via phosphatidylinositol 3-kinase (PI3K)/AKT and extracellular signal-regulated kinase (ERK)1/2 pathways. |
| Pubmed ID | 29499945 |
| Year | 2018 |
| Title | circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells Through miR-544a/FOXP1 and miR-379/FOXP2 Pathways |
External Links
| Links for circSHKBP1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |