Basic Information
LncRNA/CircRNA Name | circCullin2 |
Synonyms | circCul2, circ_10720 |
Region | |
Ensemble | |
Refseq |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | hepatocellular cancer |
ICD-0-3 | NA |
Methods | qPCR, western blot, luciferase reporter assay, RIP, other |
Sample | HCC tissues and cell lines (PLC-PRF-5 and SMMC-7721) |
Expression Pattern | NA |
Function Description | Twist1 promoted vimentin expression by increasing levels of circ-10720, which can absorb miRNAs that target vimentin. circ-10720 knockdown counteracted the tumor-promoting activity of Twist1 in vitro and in patient-derived xenograft and diethylnitrosamine-induced TetOn-Twist1 transgenic mouse HCC models. These data unveil a mechanism by which Twist1 regulates vimentin during EMT. They also provide potential therapeutic targets for HCC treatment and provide new insight for circular RNA (circRNA)-based diagnostic and therapeutic strategies |
Pubmed ID | 29844124 |
Year | 2018 |
Title | Twist1 Regulates Vimentin Through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma |
External Links
Links for circCullin2 | GenBank HGNC NONCODE |
Links for hepatocellular cancer | OMIM COSMIC |