Basic Information
| LncRNA/CircRNA Name | circCullin2 |
| Synonyms | circCul2, circ_10720 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, luciferase reporter assay, RIP, other |
| Sample | HCC tissues and cell lines (PLC-PRF-5 and SMMC-7721) |
| Expression Pattern | NA |
| Function Description | Twist1 promoted vimentin expression by increasing levels of circ-10720, which can absorb miRNAs that target vimentin. circ-10720 knockdown counteracted the tumor-promoting activity of Twist1 in vitro and in patient-derived xenograft and diethylnitrosamine-induced TetOn-Twist1 transgenic mouse HCC models. These data unveil a mechanism by which Twist1 regulates vimentin during EMT. They also provide potential therapeutic targets for HCC treatment and provide new insight for circular RNA (circRNA)-based diagnostic and therapeutic strategies |
| Pubmed ID | 29844124 |
| Year | 2018 |
| Title | Twist1 Regulates Vimentin Through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma |
External Links
| Links for circCullin2 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |