Basic Information
| LncRNA/CircRNA Name | circ_0000673 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, western blot, luciferase reporter assay, other |
| Sample | gastric cancer tissues and cell lines (AGS, MKN28, BGC823, MKN45, HGC-27, MGC803, and SGC7901), plasma |
| Expression Pattern | down-regulated |
| Function Description | The current study showed that hsa_circ_0000673 was significantly down-regulated in GC. Overexpression of hsa_circ_0000673 inhibited the proliferation and invasion of GC cells. In contrast, hsa_circ_0000673 down-regulation promoted the proliferation and invasion of GC cells. Further studies revealed that hsa_circ_0000673 targetted miR-532-5p and up-regulated the expression of RUNX3. The present study showed that hsa_circ_0000673 was decreased in GC and it exerted tumor-suppressing effects by targetting miR-532-5p and up-regulating RUNX3 expression level. Hsa_circ_0000673 may be a promising diagnosis biomarker and therapeutic target in GC. |
| Pubmed ID | 30061181 |
| Year | 2018 |
| Title | Hsa_circ_0000673 Is Down-Regulated in Gastric Cancer and Inhibits the Proliferation and Invasion of Tumor Cells by Targetting miR-532-5p |
External Links
| Links for circ_0000673 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |