Basic Information
| LncRNA/CircRNA Name | circ_0000673 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, luciferase reporter assay, other |
| Sample | HCC tissues and cell lines (Hep3B and Huh7) |
| Expression Pattern | up-regulated |
| Function Description | In terms of mechanism, we showed that hsa_circ_0000673 directly associated with miR-767-3p in HCC cells. Via inhibiting miR-767-3p, hsa_circ_0000673 promoted HCC cell proliferation and invasion. Furthermore, we demonstrated that SET was a downstream effector of hsa_circ_0000673/miR-767-3p signaling. We showed that miR-767-3p could significantly promote SET expression by sponging miR-767-3p in HCC cells. Finally, rescue assays indicated that SET expression was essential for the effects of hsa_circ_0000673/miR-767-3p signaling on HCC cell proliferation and invasion. |
| Pubmed ID | 29627570 |
| Year | 2018 |
| Title | Circular RNA hsa_circ_0000673 Promotes Hepatocellular Carcinoma Malignance by Decreasing miR-767-3p Targeting SET |
External Links
| Links for circ_0000673 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |