Basic Information
| LncRNA/CircRNA Name | circ_0001649 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Pancreatic Ductal Adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | qPCR, other |
| Sample | pancreatic cancer tissues and cell lines (SW1990, PANC1, Capan-2 and BxPC3) |
| Expression Pattern | down-regulated |
| Function Description | As a result, hsa_circ_0001649 was abnormally decreased in PDAC tissues and cells, and this down-regulation was correlated with tumor stage and differentiation grade in PDAC patients. Hsa_circ_0001649 could serve as an independent prognostic factor for PDAC patients after surgery. What's more, increased hsa_circ_0001649 caused tumor suppressive effects via reducing cell proliferation, colony-forming ability and promoting cell apoptosis in PANC1 and BxPC3 cells. |
| Pubmed ID | 29969694 |
| Year | 2018 |
| Title | A Novel Prognostic Biomarker for Pancreatic Ductal Adenocarcinoma: hsa_circ_0001649 |
External Links
| Links for circ_0001649 | GenBank HGNC NONCODE |
| Links for Pancreatic Ductal Adenocarcinoma | OMIM COSMIC |