Basic Information
| LncRNA/CircRNA Name | circ_0002052 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | OS tissues and cell lines (HOS, U2OS, MG63 and 143B) |
| Expression Pattern | down-regulated |
| Function Description | Functionally, we showed that hsa_circ_0002052 overexpression significantly suppressed OS cell proliferation, migration and invasion while promoting apoptosis in vitro. Similarly, in vivo assay indicated that ectopic expression of hsa_circ_0002052 impaired OS cell growth. In terms of mechanism, we found that hsa_circ_0002052 inhibited miR-1205 while miR1205 targeted APC2, a negative regulator of Wnt/?-catenin signaling pathway. By releasing the inhibition of miR-1205 on APC2 expression, hsa_circ_0002052 suppressed the activation of Wnt/?-catenin signaling pathway, leading to attenuated OS progression. Taken together, our study for the first time revealed a suppressive circRNA hsa_circ_0002052 involved in OS progression. |
| Pubmed ID | 29852168 |
| Year | 2018 |
| Title | Overexpressing Circular RNA hsa_circ_0002052 Impairs Osteosarcoma Progression via Inhibiting Wnt/?-catenin Pathway by Regulating miR-1205/APC2 Axis |
External Links
| Links for circ_0002052 | GenBank HGNC NONCODE |
| Links for Osteosarcoma | OMIM COSMIC |