Basic Information
| LncRNA/CircRNA Name | circ_0007534 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Breast Cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, western blot, luciferase reporter assay, other |
| Sample | BC tissues and cell lines (MCF-1, MDA-MB-231, MDA-MB-468, SKBR-3,and MDA-MB-453) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of hsa_circ_0007534 inhibited BC cell proliferation, colony formation, and invasion, and promoted apoptosis in BC cells. Moreover, hsa_circ_0007534 was demonstrated to be a sponge of miR-593, and expression of miR-593 in BC cells was negatively correlated with hsa_circ_0007534. MUC19 expression was markedly increased in BC tissues and cell lines, and the 3'-UTR of MUC19 was targeted by miR-593. The expression of MUC19 was negatively regulated by miR-593 in BC cells. |
| Pubmed ID | 30139516 |
| Year | 2018 |
| Title | Downregulation of hsa_circ_0007534 Suppresses Breast Cancer Cell Proliferation and Invasion by Targeting miR-593/MUC19 Signal Pathway |
External Links
| Links for circ_0007534 | GenBank HGNC NONCODE |
| Links for Breast Cancer | OMIM COSMIC |