Basic Information
| LncRNA/CircRNA Name | circ_0007534 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Colorectal Cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, western blot, other |
| Sample | CRC tissues and cell lines (SW620, HCT116, LoVo, SW480, and HT29) |
| Expression Pattern | up-regulated |
| Function Description | We analyzed a cohort of 33 patients with CRC and demonstrated that the expression of hsa_circ_0007534 was significantly up-regulated in CRC tumor tissues as compared to adjacent non-tumorous tissues. Moreover, hsa_circ_0007534 expression was correlated with tumor stage and lymph node metastasis. Furthermore, the silence of hsa_circ_0007534 by siRNA significantly inhibited proliferation and induced apoptosis of CRC cells. |
| Pubmed ID | 29364478 |
| Year | 2018 |
| Title | Silencing of hsa_circ_0007534 Suppresses Proliferation and Induces Apoptosis in Colorectal Cancer Cells |
External Links
| Links for circ_0007534 | GenBank HGNC NONCODE |
| Links for Colorectal Cancer | OMIM COSMIC |