Basic Information
LncRNA/CircRNA Name | circ_0008039 |
Synonyms | |
Region | |
Ensemble | |
Refseq |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | Breast Cancer |
ICD-0-3 | C50 |
Methods | qPCR, luciferase reporter assay, other |
Sample | Breast cancer tissues and cell lines (BT-20, BT-474, MCF-7, BT549, MDA-MB231, and SKBR-3) |
Expression Pattern | up-regulated |
Function Description | By functional experiments, we found that hsa_circ_0008039 depletion significantly suppressed the proliferation, arrested cell-cycle progression and reduced migration in breast cancer. Mechanistic investigations suggested that hsa_circ_0008039 served as a competing endogenous RNA (ceRNA) of miR-432-5p. Subsequently, E2F3 was identified as the functional target of miR-432-5p and overexpression of hsa_circ_0008039 elevated E2F3 expression in breast cancer.? |
Pubmed ID | 29807010 |
Year | 2018 |
Title | Circular RNA hsa_circ_0008039 Promotes Breast Cancer Cell Proliferation and Migration by Regulating miR-432-5p/E2F3 Axis |
External Links
Links for circ_0008039 | GenBank HGNC NONCODE |
Links for Breast Cancer | OMIM COSMIC |