Basic Information
| LncRNA/CircRNA Name | circ_0008039 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Breast Cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | Breast cancer tissues and cell lines (BT-20, BT-474, MCF-7, BT549, MDA-MB231, and SKBR-3) |
| Expression Pattern | up-regulated |
| Function Description | By functional experiments, we found that hsa_circ_0008039 depletion significantly suppressed the proliferation, arrested cell-cycle progression and reduced migration in breast cancer. Mechanistic investigations suggested that hsa_circ_0008039 served as a competing endogenous RNA (ceRNA) of miR-432-5p. Subsequently, E2F3 was identified as the functional target of miR-432-5p and overexpression of hsa_circ_0008039 elevated E2F3 expression in breast cancer.? |
| Pubmed ID | 29807010 |
| Year | 2018 |
| Title | Circular RNA hsa_circ_0008039 Promotes Breast Cancer Cell Proliferation and Migration by Regulating miR-432-5p/E2F3 Axis |
External Links
| Links for circ_0008039 | GenBank HGNC NONCODE |
| Links for Breast Cancer | OMIM COSMIC |