Basic Information
| LncRNA/CircRNA Name | circ_0011946 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Breast Cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNA-seq, other |
| Sample | breast cancer tissues and cell lines (HS-578T, T47D, MCF-7, BT549,MDA-MB-231, and SKBR-3) |
| Expression Pattern | up-regulated |
| Function Description | Out of these, hsa_circ_0011946 was selected and the subsequent bioinformatics analysis predicted that hsa_circ_0011946 sponging miR-26a/b directly targeted replication factor C subunit 3 (RFC3) and that its knockdown could inhibit RFC3 mRNA and protein expression. Furthermore, hsa_circ_0011946 loss-of-function significantly suppressed the migration and invasion of Michigan Cancer Foundation-7 cells. |
| Pubmed ID | 29593432 |
| Year | 2018 |
| Title | Downregulation of hsa_circ_0011946 Suppresses the Migration and Invasion of the Breast Cancer Cell Line MCF-7 by Targeting RFC3 |
External Links
| Links for circ_0011946 | GenBank HGNC NONCODE |
| Links for Breast Cancer | OMIM COSMIC |