Basic Information
| LncRNA/CircRNA Name | circ_0014130 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Microarray, other |
| Sample | NSCLC tissues |
| Expression Pattern | up-regulated |
| Function Description | Only hsa_circ_0014130 exhibited significantly overexpressed in NSCLC tissues (P < 0.001), which were further confirmed in another 36 matched tissue samples using qRT-PCR. Hsa_circ_0014130 expression significantly correlated with TNM stage (P = 0.001) and lymphatic metastasis (P = 0.004). The area under the receiver operating characteristic curve was 0.878 (95% confidence interval = 0.804-0.951; P < 0.001), which showed good diagnostic potential. Bioinformatics platforms predicted that hsa_circ_0014130 might interact with five miRNAs and their corresponding mRNAs. Gene oncology analysis and pathway analysis revealed that hsa_circ_0014130 could participate in NSCLC development. |
| Pubmed ID | 29440731 |
| Year | 2018 |
| Title | Microarray Profile of Circular RNAs Identifies hsa_circ_0014130 as a New Circular RNA Biomarker in Non-Small Cell Lung Cancer |
External Links
| Links for circ_0014130 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |