Basic Information
| LncRNA/CircRNA Name | circ_0014717 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, western blot, other |
| Sample | CRC tissues and cell lines (HCT116, HT29 and SW480) |
| Expression Pattern | down-regulated |
| Function Description | Moreover, our gain-of-function analysis further showed that hsa_circ_0014717 overexpression could significantly suppress CRC cell proliferation and colony formation, as well as induce cell cycle G0/G1 phase arrest in vitro and inhibit xenograft tumor growth in vivo. In addition, hsa_circ_0014717 could upregulate the expression of cell cycle inhibitory protein p16. Besides, p16 knockdown could reverse hsa_circ_0014717 mediated growth inhibition of CRC cells. |
| Pubmed ID | 29571246 |
| Year | 2018 |
| Title | Hsa_circ_0014717 Is Downregulated in Colorectal Cancer and Inhibits Tumor Growth by Promoting p16 Expression |
External Links
| Links for circ_0014717 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |