Basic Information
| LncRNA/CircRNA Name | circ_0023404 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | cervical cancer tissues and cell lines (SiHa, C-33a, CaSki,C4-1 and Hela) |
| Expression Pattern | up-regulated |
| Function Description | Functionally, we showed that knockdown of hsa_circ_0023404 significantly suppressed the proliferation, arrested the cell-cycle progression and inhibited cell migration and invasion in CC. In terms of mechanism, we found that hsa_circ_0023404 acted as a sponge of miR-136 and miR-136 targeted TFCP2, which is an activator of YAP signaling pathway. We showed that hsa_circ_0023404 activated YAP pathway in CC via promoting TFCP2 expression by sponging miR-136, leading to CC development and progression. |
| Pubmed ID | 29738762 |
| Year | 2018 |
| Title | Circular RNA hsa_circ_0023404 Exerts an Oncogenic Role in Cervical Cancer Through Regulating miR-136/TFCP2/YAP Pathway |
External Links
| Links for circ_0023404 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |