Basic Information
| LncRNA/CircRNA Name | circ_0025036 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Lung Adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, western blot, luciferase reporter assay, RNAi, other |
| Sample | Lung adenocarcinoma tissues and cell lines (A549 and Calu-3) |
| Expression Pattern | up-regulated |
| Function Description | Its expression level exhibited a close link with aggressive clinicopathological parameters including cancer differentiation, TNM stage and lymph node metastasis. hsa_circ_0025036 knockdown significantly suppressed cell proliferation and promoted cell apoptosis in A549 and Calu-3 cells. Moreover, hsa_circ_0025036/miR-198/SHMT1&TGF-? axis was identified via bioinformatics analysis and Dual-Luciferase Reporter assays. miR-198 inhibitors reversed the function of hsa_circ_0025036 knockdown. hsa_circ_0025036 knockdown exerted similar effects with miR-198 upregulation on cell proliferation and apoptosis. |
| Pubmed ID | 30138108 |
| Year | 2018 |
| Title | Aberrant Expression of hsa_circ_0025036 in Lung Adenocarcinoma and Its Potential Roles in Regulating Cell Proliferation and Apoptosis |
External Links
| Links for circ_0025036 | GenBank HGNC NONCODE |
| Links for Lung Adenocarcinoma | OMIM COSMIC |