Basic Information
| LncRNA/CircRNA Name | circ_0025039 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | T cell | Survival | ||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, other, luciferase reporter assay, RNAi |
| Sample | melanoma tissues and cell lines (A375, SK-MEL-1, A2058 and 293 T cell) |
| Expression Pattern | up-regulated |
| Function Description | In particular, we found that hsa_circ_0025039, which is formed by FOXM1 exons, is significantly upregulated in melanoma. In vitro, the knockdown of circ_0025039 inhibited cell proliferation, colony formation ability, invasion and glucose metabolism in melanoma cells. Additionally, we identified miR-198 as a direct target of hsa_circ_0025039. Furthermore, we demonstrated that hsa_circ_0025039 regulates CDK4 expression by sponging miR-198. In vivo study indicated that the silencing of hsa_circ_0025039 inhibits melanoma tumor formation and downregulates miR-198 and CDK4 expression. |
| Pubmed ID | 30219673 |
| Year | 2018 |
| Title | Novel Circular RNA, hsa_circ_0025039 Promotes Cell Growth, Invasion and Glucose Metabolism in Malignant Melanoma via the miR-198/CDK4 Axis |
External Links
| Links for circ_0025039 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |