Basic Information
| LncRNA/CircRNA Name | circ_010253 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, Microarray, other |
| Sample | NSCLC tissues and cell lines (A549, H1299, H1792,SK-MES-1 and SPC-A1), blood |
| Expression Pattern | up-regulated |
| Function Description | Compared with the control group, hsa_circ_0102533 expression was significantly increased in tumor tissues and whole blood from NSCLC patients. ROC analysis showed that hsa_circ_0102533 had a higher diagnostic power for the detection of cancer in stage I-II NSCLC patients [AUC: 0.774 (95% CI: 0.624-0.923)] than in stage III-IV NSCLC patients [0.728 (95% CI: 0.588-0.869)]. Furthermore, the knockout of hsa_circ_0102533 by siRNA significantly inhibited proliferation and induced apoptosis in NSCLC cell lines. |
| Pubmed ID | 31949836 |
| Year | 2018 |
| Title | Hsa_circ_0102533 Serves as a Blood-Based Biomarker for Non-Small-Cell Lung Cancer Diagnosis and Regulates Apoptosis in Vitro |
External Links
| Links for circ_010253 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |