Basic Information
| LncRNA/CircRNA Name | circ_0103809 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, luciferase reporter assay, other |
| Sample | liver cancer tissues and cell lines (MHCC97H,HepG2, Huh7, SMMC7721 and SK-Hep1) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of hsa_circ_0103809 inhibited proliferation and migration and induced apoptosis in HCC cell lines. Investigation to the molecular mechanisms of hsa_circ_0103809 in HCC cells had revealed that hsa_circ_0103809 directly suppressed miR-490-5p, which targeted to the 3'-UTR of SOX2. Hsa_circ_0103809 loss-of-function could increase the expression of miR-490-5p as well as decreased the expression of SOX2. Furthermore, we found that si-0103809 induced growth and migration inhibition and apoptosis could be reversed by transfected with miR-490-5p inhibitors or SOX2 in HCC cells. |
| Pubmed ID | 30018710 |
| Year | 2018 |
| Title | Hsa_circ_0103809 Promotes Cell Proliferation and Inhibits Apoptosis in Hepatocellular Carcinoma by Targeting miR-490-5p/SOX2 Signaling Pathway |
External Links
| Links for circ_0103809 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |