Basic Information
| LncRNA/CircRNA Name | circ_0141940 |
| Synonyms | circMYLK |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, other |
| Sample | PCa tissues and cell lines (DU145, LNCaP, PC-3, and PC-3MIE8 cells) |
| Expression Pattern | up-regulated |
| Function Description | In the present study, we confirmed that circMYLK expression level was significantly higher in PCa samples and PCa cells than in normal tissues and normal prostatic cells. The upregulated circRNA-MYLK promoted PCa cells proliferation, invasion, and migration; however, si-circRNA-MYLK significantly accelerated the PCa cell apoptosis. We also observed that the aforementioned function of circRNA-MYLK on PCa cells was affected through targeting miR-29a. |
| Pubmed ID | 29798970 |
| Year | 2018 |
| Title | Circular RNA Myosin Light Chain Kinase (MYLK) Promotes Prostate Cancer Progression Through Modulating Mir-29a Expression |
External Links
| Links for circ_0141940 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |