Basic Information
LncRNA/CircRNA Name | circ_103809 |
Synonyms | |
Region | |
Ensemble | |
Refseq |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | Lung Cancer |
ICD-0-3 | C34 |
Methods | qPCR, luciferase reporter assay, other |
Sample | lung cancer tissues and cell lines (A549, H125, 95D, NCI-H292 and H1975) |
Expression Pattern | up-regulated |
Function Description | Furthermore, we found that hsa_circRNA_103809 knockdown significantly suppressed lung cancer cell proliferation and invasion in vitro and delayed tumor growth in vivo. In mechanism, we identified hsa_circRNA_103809 as a sponge of miR-4302 targeting ZNF121. By sequestering miR-4302, hsa_circRNA_103809 promoted the expression of ZNF121 which consequently enhanced MYC protein level in lung cancer cells. Through rescue assays, we demonstrated hsa_circRNA_103809 contributed to lung cancer cell proliferation and invasion via facilitating ZNF121-dependent MYC expression by sponging miR-4302. |
Pubmed ID | 29698681 |
Year | 2018 |
Title | Circular RNA hsa_circRNA_103809 Promotes Lung Cancer Progression via Facilitating ZNF121-dependent MYC Expression by Sequestering miR-4302 |
External Links
Links for circ_103809 | GenBank HGNC NONCODE |
Links for Lung Cancer | OMIM COSMIC |