Basic Information
| LncRNA/CircRNA Name | circ_103809 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Lung Cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | lung cancer tissues and cell lines (A549, H125, 95D, NCI-H292 and H1975) |
| Expression Pattern | up-regulated |
| Function Description | Furthermore, we found that hsa_circRNA_103809 knockdown significantly suppressed lung cancer cell proliferation and invasion in vitro and delayed tumor growth in vivo. In mechanism, we identified hsa_circRNA_103809 as a sponge of miR-4302 targeting ZNF121. By sequestering miR-4302, hsa_circRNA_103809 promoted the expression of ZNF121 which consequently enhanced MYC protein level in lung cancer cells. Through rescue assays, we demonstrated hsa_circRNA_103809 contributed to lung cancer cell proliferation and invasion via facilitating ZNF121-dependent MYC expression by sponging miR-4302. |
| Pubmed ID | 29698681 |
| Year | 2018 |
| Title | Circular RNA hsa_circRNA_103809 Promotes Lung Cancer Progression via Facilitating ZNF121-dependent MYC Expression by Sequestering miR-4302 |
External Links
| Links for circ_103809 | GenBank HGNC NONCODE |
| Links for Lung Cancer | OMIM COSMIC |