Basic Information
| LncRNA/CircRNA Name | circITCH |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Glioma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, RIP, other |
| Sample | glioma tissues and cell lines (U87, U251, A172,SHG44, LN229, T98G and SHG139) |
| Expression Pattern | down-regulated |
| Function Description | Cir-ITCH significantly promoted the capacities of cell proliferation, migration and invasion of glioma cells. The linear isomer of cir-ITCH, ITCH gene was then identified as the down stream target. Subsequently, RNA immunoprecipitation clearly showed that cir-ITCH sponged miR-214, which further promoted the ITCH expression. Finally, the gain and loss functional assays indicate that cir-ITCH plays an anti-oncogenic role through sponging miR-214 and regulating ITCH-Wnt/?-catenin pathway. These results suggest that cir-ITCH is a tumor-suppressor gene in glioma and may serve as a promising prognostic biomarker for glioma patients. |
| Pubmed ID | 29887952 |
| Year | 2018 |
| Title | Identification of the Tumor-Suppressive Function of Circular RNA ITCH in Glioma Cells Through Sponging miR-214 and Promoting Linear ITCH Expression |
External Links
| Links for circITCH | GenBank HGNC NONCODE |
| Links for Glioma | OMIM COSMIC |