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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	Lung Adenocarcinoma
ICD-0-3	C34
Methods	qPCR
Sample	tumor tissues and lung cancer cell lines (A549 & H1299), normal tissues or human pulmonary bronchial epidermal cell lines (BEAS-2B, B2B)
Expression Pattern	down-regulated
Function Description	To confirm the microarray data, we randomly selected five differentially expressed circRNAs, including two up-regulated (hsa_circRNA_406483 and hsa_circRNA_404833) and three down-regulated (hsa_circRNA_001640, hsa_circRNA_006411 and hsa_ circRNA_401977) circRNAs the expression patterns of selected circRNAs were consistent with the microarray data in the tumor samples (Fig. 3A), but the expression of hsa_circRNA_406483 and hsa_circRNA_001640 in the lung cancer cell lines did not match well with the microarray data, the PCR products were cloned into a pEasy-3T vector for further sequence identification, and the results showed that those PCR products were exactly the indicated circRNAs with a back spliced junction, and the cyclic patterns of circRNAs were described according to the associated gene exons.
Pubmed ID	29241190
Year	2017
Title	CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients

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