Basic Information
| LncRNA/CircRNA Name | circ_0018289 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | PCR, Cell proliferation assay, Migration and invasion assay, luciferase reporter assay |
| Sample | cervical cancer tissue and matched non-tumor tissue, Cervical cancer cells (HeLa, CaSki, SiHa, HT-3 and C33A), human epidermal cell (HaCaT) |
| Expression Pattern | up-regulated |
| Function Description | Among these up-regulated circRNAs, hsa_ circ_0018289 was validated to be significantly up-regulated in 35 pairs of cervical cancer tissue compared with adjacent normal tissue and cell lines. Loss-of-function experiments revealed that, in vitro and in vivo, hsa_circ_0018289 knockdown inhibited the proliferation, migration and invasion of cervical cancer cells. Via bioinformatics prediction program and luciferase reporter assays, hsa_circ_0018289 was observed to directly bind to miR-497. |
| Pubmed ID | 29156822 |
| Year | 2017 |
| Title | Circular RNA expression profiles reveal that hsa_circ_0018289 is up-regulated in cervical cancer and promotes the tumorigenesis |
External Links
| Links for circ_0018289 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |