Basic Information
| LncRNA/CircRNA Name | circGFRA1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, CCK8 assay, Colony formation assay, Cell apoptosis assay, Luciferase reporter assay, RNA immunoprecipitation (RIP) assay, Western blot analysis |
| Sample | Tumor and paired adjacent normal mammal tissues, human mammary epithelial (HME) cell lines (MCF10A and 184A1) and breast cancer cell lines (SKBR3, T47D, BT474, MCF-7, BT-483, BT-20, BT549, MDA-MB-468 and MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | Microarray analysis and qRT-PCR verified a circRNA termed circGFRA1 that was upregulated in TNBC. KaplanMeier survival analysis showed that upregulated circGFRA1 was correlated with poorer survival. Knockdown of circGFRA1 inhibited proliferation and promoted apoptosis in TNBC. Via luciferase reporter assays, circGFRA1 and GFRA1 was observed to directly bind to miR-34a. Subsequent experiments showed that circGFRA1 and GFRA1 regulated the expression of each other by sponging miR-34a. |
| Pubmed ID | 29037220 |
| Year | 2017 |
| Title | circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a |
External Links
| Links for circGFRA1 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |