Basic Information
| LncRNA/CircRNA Name | circ_7690-15 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, RNA fluorescence in situ hybridization (RNA FISH), Cell proliferation assay, Matrigel invasion assay, Western blot analysis |
| Sample | GC tissue and paired adjacent noncancerous mucosal tissue, The human GC cell line AGS |
| Expression Pattern | up-regulated |
| Function Description | we observed three newly identified circRNAs that are substantially upregulated in GC: hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15. Additionally, hsa_circ_0047905 and hsa_circ_0138960 positively correlated with their parental gene mRNA. Knockdown of hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 in GC cells, resulted in downregulation of parental gene expression. Functional assays suggested that inhibition of these three circular RNAs suppresses GC cell proliferation and invasion in vitro. |
| Pubmed ID | 28980874 |
| Year | 2017 |
| Title | Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and hascircRNA7690-15 are candidate oncogenes in gastric cancer |
External Links
| Links for circ_7690-15 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |