Basic Information
| LncRNA/CircRNA Name | circ_104980 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Osteosarcoma |
| ICD-0-3 | NA |
| Methods | PCR |
| Sample | The human osteoblast hFOB1.19 and the human osteosarcoma cell lines U2OS, MG63, HOS and 143B, The ZOS and ZOS-M cell lines, 15 tumor tissues and 15 paired normal tissues |
| Expression Pattern | down-regulated |
| Function Description | We revealed a number of GLIIHUHQWLDOO\H[SUHVVHGFLUF51$VDQGRIWKHPZHUHFRQ?UPHGZKLFKVXJJHVWVDSRWHQWLDO role of circRNAs in OS. Among these differentially expressed circRNAs, hsa_circRNA_103801 was up-regulated in both osteosarcoma cell lines and tissues, while hsa_circRNA_104980 was down-regulated. The most likely potential target miRNAs for hsa_circRNA_103801 include hsamiR-370-3p, hsa-miR-338-3p and hsa-miR-877-3p, while the most potential target miRNAs of hsa_circRNA_104980 consist of hsa-miR-1298-3p and hsa-miR-660-3p. Functional analysis IRXQGWKDWKVDBFLUF51$BZDVLQYROYHGLQSDWKZD\VLQFDQFHUVXFKDVWKH+,)9(*) and angiogenesis pathway, the Rap1 signaling pathway and the PI3K-Akt signaling pathway, while hsa_circRNA_104980 was related to some pathways such as the tight junction pathway |
| Pubmed ID | 28957794 |
| Year | 2017 |
| Title | Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma |
External Links
| Links for circ_104980 | GenBank HGNC NONCODE |
| Links for Osteosarcoma | OMIM COSMIC |