Basic Information
| LncRNA/CircRNA Name | circ_0004018 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | Reverse transcription, PCR |
| Sample | The para-tumorous tissues, liver tissues, HCC cell lines, HepG2, Huh7, SMMC-7721, MHCC97H and HCCLM3, and human normal hepatic cell line L02 |
| Expression Pattern | down-regulated |
| Function Description | The expression levels of hsa_circ_0004018 in HCC were significantly lower compared with para-tumorous tissue (P<0.001). Our data further showed that lower expression of hsa_circ_0004018 was correlated with serum alpha-fetoprotein (AFP) level, tumor diameters, differentiation, Barcelona Clinic Liver Cancer stage and Tumor-node-metastasis stage. More importantly, we detected liver tissues from chronic hepatitis, cirrhosis and HCC patients; and found that hsa_ circ_0004018 harbored HCC-stage-specific expression features in diverse chronic liver diseases (P<0.001). The area under receiver operating characteristic curve was up to 0.848 (95% CI=0.803-0.894, P<0.001). The sensitivity and specificity were 0.716 and 0.815, respectively. |
| Pubmed ID | 28938566 |
| Year | 2017 |
| Title | Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma |
External Links
| Links for circ_0004018 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |