Basic Information
| LncRNA/CircRNA Name | circLARP4 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blotting analysis, Colony formation assay, Luciferase reporter assay, 5-Ethynyl-20-deoxyuridine (EdU) incorporation assay, RNA immunoprecipitation (RIP), RNA fluorescence in situ hybridization (FISH) |
| Sample | GC patients and 41 adjacent normal tissues, Normal human gastric epithelial cell line GES-1 and GC cell lines (SGC-7901, MKN-45, MKN-28, HGC-27, MGC803, AGS, BGC-823) |
| Expression Pattern | down-regulated |
| Function Description | Increased miR-424 expression or decreased LATS1 expression was associated with pathological stage and unfavorable prognosis of GC patients. Ectopic expression of miR-424 promoted proliferation and invasion of GC cells by targeting LATS1 gene. Furthermore, circLARP4 was mainly localized in the cytoplasm and inhibited biological behaviors of GC cells by sponging miR-424. The expression of circLARP4 was downregulated in GC tissues and represented an independent prognostic factor for overall survival of GC patients. |
| Pubmed ID | 28893265 |
| Year | 2017 |
| Title | Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression |
External Links
| Links for circLARP4 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |