Detail

Basic Information

LncRNA/CircRNA Name	circDENND4C
Synonyms
Region
Ensemble
Refseq

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	Breast Cancer
ICD-0-3	C50
Methods	CCK-8 kit assay, PCR, Western blot analysis
Sample	breast and adjacent non-cancerous breast tissues, MCF-7 and MDA-MB-231 cell lines
Expression Pattern	up-regulated
Function Description	In breast cancer cells, circDENND4C was increased under hypoxic conditions and decreased after knocking-down HIF1?. In addition, knocking-down circDENND4C inhibited proliferation of breast cancer cells in a hypoxic environment. Finally, tumors with a large size had higher circDENND4C expression levels than those of small size.
Pubmed ID	28739726
Year	2017
Title	HIF1?-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment

External Links

Links for circDENND4C	GenBank HGNC NONCODE
Links for Breast Cancer	OMIM COSMIC