Basic Information
| LncRNA/CircRNA Name | circ_000839 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | PCR, Transwell invasion assays, Immunofluorescence staining, Western blot analysis, Luciferase assay, Transient transfection of RhoA plasmid, Wound-healing assay |
| Sample | The Huh7 and HepG2 HCC cell lines, The hepatocellular cancer tissues, adjacent normal liver tissues |
| Expression Pattern | up-regulated |
| Function Description | miR-200b is expressed at a relatively low level in hepatocellular carcinoma (p<0.001). RhoA and circ_000839 are expressed at a relatively high level in hepatocellular carcinoma (p<0.001, respectively). Our mechanistic data indicate that RhoA is a direct target of miR-200b (p<0.001), binding of which affects the expression of invasion and migration in hepatocellular carcinoma cell lines (p<0.05). And correlation analysis showed that miR-200b was inversely correlated with RhoA and circ_000839 (p=0.012, p=0.002, respectively), while RhoA was positively correlated with circ_000839 (p<0.001). |
| Pubmed ID | 28695771 |
| Year | 2017 |
| Title | MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839 |
External Links
| Links for circ_000839 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |