Basic Information
| LncRNA/CircRNA Name | circ_100269 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Dual Luciferase assay and vector construction , Cell proliferation assay |
| Sample | Human colorectal cancer cell lines, namely, AGS, MKN28, MKN45, BGC823, MGC803, SGC7901, and GES1, GC tissues, the corresponding adjacent non-cancerous tissues |
| Expression Pattern | down-regulated |
| Function Description | The expression levels of circRNA_100269 and its linear isomer LPHN2 mRNA were found to be downregulated (p<0.01) in GC tissues. The target miRNA was predicted to be miR-630, whose expression was upregulated (p<0.01) and found to be negatively correlated with that of circRNA_100269 (r =? -0.688) in GC tissues. Moreover, direct interaction of circRNA_100269 and miR-630 was confirmed through dual-luciferase assays. Overexpressing the circRNA_100269 plasmid inhibited cell proliferation (p<0.05). Furthermore, transfection of miR-630 mimics into cell lines overexpressing circRNA_100269 blocked the function of circRNA_100269 (p<0.05). |
| Pubmed ID | 28657541 |
| Year | 2017 |
| Title | CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630 |
External Links
| Links for circ_100269 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |