Basic Information
| LncRNA/CircRNA Name | circ_0000096 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Transient transfection, Western blot, Cell cycle analysis, Cell apoptosis analysis, Cell proliferation assay, Cell migration assay, Immunohistochemical analysis |
| Sample | gastric cancer tissues, paired adjacent non-tumorous tissues, Five human gastric cancer cell lines, AGS, BGC-823, HGC-27, SGC-7901 and MGC-803, The human gastric epithelial cell line GES-1 |
| Expression Pattern | down-regulated |
| Function Description | Hsa_circ_0000096 was found to be significantly downregulated in gastric cancer tissues and gastric cancer cell lines compared with paired adjacent non-tumorous tissues and normal gastric epithelial cells (Po0.001). Moreover, knockdown of hsa_circ_0000096 significantly inhibited cell proliferation and migration in vitro and in vivo. The results of both immunohistochemical and western blot analyses showed that the protein levels of cyclin D1, cyclin-dependent kinase 6 (CDK6), matrix metalloproteinase-2 and MMP-9 were significantly reduced in vitro and in vivo. A gastric cancer xenograft nude mouse model indicated that Ki67 and VEGF were reduced in a dose-dependent manner following knockdown of hsa_circ_0000096. However, the expression of E-cadherin increased. |
| Pubmed ID | 28081541 |
| Year | 2017 |
| Title | Circular RNA 0000096 affects cell growth and migration in gastric cancer |
External Links
| Links for circ_0000096 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |