Basic Information
| LncRNA/CircRNA Name | circ_0000069 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Cell transfection, Cell proliferation assays, Flow cytometric analysis, Cell migration and invasion assays |
| Sample | CRC tissues and adjacent noncancerous tissues, CRC cell lines (HT-29, LoVo, HCT-116 and SW480) and one normal intestinal epithelial cell line (HCO) |
| Expression Pattern | up-regulated |
| Function Description | circ_0000069 was measured in 30 paired CRC tissues and adjacent noncancerous tissues using quantitative polymerase chain reaction. A high expression of hsa_circ_0000069 was observed in CRC tissues and correlated with patients??age and tumor, node, metastasis (TNM) stage (P,0.05). Furthermore, by using specifically designed siRNAs in CRC cells, a functional analysis was performed which revealed that hsa_circ_0000069 knockdown could notably inhibit cell proliferation, migration, and invasion, and induce G0/G1 phase arrest of cell cycle in vitro. |
| Pubmed ID | 28003761 |
| Year | 2017 |
| Title | Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer |
External Links
| Links for circ_0000069 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |