Basic Information
| LncRNA/CircRNA Name | circITCH |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Lung Cancer |
| ICD-0-3 | C34 |
| Methods | PCR, Transient Transfections and Luciferase Assays, Actinomycin D Assay, Western blotting, Cell Viability Assay |
| Sample | lung cancer biopsy specimens and paired adjacent normal tissues, Human lung cancer cell lines A549 and NCI-H460 |
| Expression Pattern | down-regulated |
| Function Description | we firstly detected the expression of cir-ITCH in tumor tissues and paired adjacent noncancer tissues of 78 patients with lung cancer using a TaqMan-based quantitative real-time PCR (qRT-PCR). The results showed that the expression of cir-ITCH was significantly decreased in lung cancer tissues. In cellular studies, cir-ITCH was also enhanced in different lung cancer cell lines, A549 and NIC-H460. Ectopic expression ofcir-ITCH markedly elevated its parental cancer-suppressive gene, ITCH, expression and inhibited proliferation of lung cancer cells. Molecular analysis further revealed that cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/beta-catenin signaling |
| Pubmed ID | 27642589 |
| Year | 2017 |
| Title | Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/ |
External Links
| Links for circITCH | GenBank HGNC NONCODE |
| Links for Lung Cancer | OMIM COSMIC |