Basic Information
| LncRNA/CircRNA Name | circ_001569 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Luciferase activity assays, RT-PCR, Western blotting, Proliferation, cell cycle, apoptosis and cell invasion assays in vitro and in vivo tumorigenicity assay |
| Sample | CRC tissue samples and matched non-tumor normal tissue, 293T, HCT116, SW620 and LOVO cells |
| Expression Pattern | up-regulated |
| Function Description | hsa_circ_001569 acted as a positive regulator in cell proliferation and invasion of colorectal cancer (CRC). Moreover, hsa_circ_001569 was identified as a sponge of miR-145 and up-regulated miR-145 functional targets E2F5, BAG4 and FMNL2. In CRC tissues, circ_001569 negatively correlated with miR-145, and miR145 correlated negatively with E2F5, BAG4 and FMNL2 expressions. Our study reveals a novel regulatory mechanism of circ_001569 in cell proliferation and invasion in CRC, provides a comprehensive landscape of circ_001569 that will facilitate further biomarker discoveries in the progression of CRC. |
| Pubmed ID | 27058418 |
| Year | 2017 |
| Title | Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer |
External Links
| Links for circ_001569 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |