Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | GRCh38_8:127207382-127219268 |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | gastric cancer tissues, cell lines (MKN45, Hs746T, SGC-7901, GES-1) |
| Expression Pattern | up-regulated |
| Function Description | miR-219-1 was predicted and convinced a direct target of CCAT1. The expression of miR-219-1 was declined in GC tissues and GC cell lines.the roles of CCAT1 on cell proliferation, apoptosis and invasion were inhibited by miR-219-1.tumor growth of GC was suppressed through knockdown of CCAT1.CAT1 promotes the tumorigenesis and progression of GC by negative-regulating miR-219-1. |
| Pubmed ID | 29231252 |
| Year | 2017 |
| Title | LncRNA CCAT1 contributes to the growth and invasion of gastric cancer via targeting miR-219-1. |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |