Basic Information
| LncRNA/CircRNA Name | ACTA2-AS1:4 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, etc. |
| Sample | Liver cancer tissues, Liver cancer cell lines, LM3, MHCC-97L, and MHCC-97L, and the normal liver cell line, L02 |
| Expression Pattern | up-regulated |
| Function Description | The present study addressed the potential role of ACTA2-AS1:4, one of the transcript variantss of ACTA2-AS1, in liver cancer development by analyzing its expression in liver cancer tissues and also multiple liver cancer cell lines. Furthermore, ACTA2-AS1 was inhibited using specific siRNAs to investigate the role of ACTA2-AS1 in regulating liver cancer cell proliferation, invasion and migration. This provided important information for understanding the function of lncRNAs during hepatic tumorigenesis.The lncRNA ACTA2 antisense RNA 1 (ACTA2-AS1) encoded by ACTA2 |
| Pubmed ID | 30664183 |
| Year | 2019 |
| Title | Knockdown of ACTA2-AS1 promotes liver cancer cell proliferation, migration and invasion |
External Links
| Links for ACTA2-AS1:4 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |