Basic Information
| LncRNA/CircRNA Name | CCAT2 |
| Synonyms | CCAT2, LINC00873, NCCP1 |
| Region | GRCh38_8:127400399-127402150 |
| Ensemble | ENSG00000280997 |
| Refseq | NR_109834 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | ESCC tissues, cell line (KYSE410) |
| Expression Pattern | up-regulated |
| Function Description | In silico analysis showed that no CpG island is found in the chromosome region of CCAT2, indicating that the expression of CCAT2 is possibly not regulated by DNA methylation.Compared with paired adjacent normal esophageal tissues, CCAT2 was significantly overexpressed in ESCC tissues with an average fold of 7.18. In ESCC cell lines, CCAT2 was mostly upregulated in KYSE410 cell when normalized to normal esophageal epithelium cell line (HEEC) and most CCAT2 transcripts were located in nucleus. Statistical analysis showed that CCAT2 expression level was significantly associated with smoking status. |
| Pubmed ID | 25677908 |
| Year | 2015 |
| Title | Long noncoding RNA CCAT2 correlates with smoking in esophageal squamous cell carcinoma. |
External Links
| Links for CCAT2 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |