Basic Information
| LncRNA/CircRNA Name | CCAT8 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Microarray, qPCR, Luciferase reporter assay etc. |
| Sample | CRC tissues, cell lines (HCT116, RKO, HT29, SW620 etc.) |
| Expression Pattern | down-regulated |
| Function Description | Of the seletced lncRNAs, four lncRNAs named CCAT3, CCAT4, CCAT5, and CCAT6 (also named MYCLo-2) are upregulated in CRC cell lines, and two lncRNAs named CCAT7 and CCAT8 are downregulated in CRC cell lines. MYC-regulated lncRNAs, named MYCLos. The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. |
| Pubmed ID | 25663692 |
| Year | 2015 |
| Title | Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis. |
External Links
| Links for CCAT8 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |