Basic Information
| LncRNA/CircRNA Name | CCDC26 |
| Synonyms | NA |
| Region | GRCh38_8:128634199-129683679 |
| Ensemble | ENSG00000229140 |
| Refseq | NR_130917 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | imatinib | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastrointestinal stromal tumor |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | Human GIST cell lines (GIST-882 and GIST-T1) |
| Expression Pattern | up-regulated |
| Function Description | GIST cells with high expression of CCDC26 were sensitive to imatinib treatment while knockdown of CCDC26 significantly increased the resistance to imatinib.CCDC26 interacted with c-KIT by RNA pull down, and that CCDC26 knockdown up-regulated the expression of IGF-1R.Moreover, IGF-1R inhibition reversed CCDC26 knockdown-mediated imatinib resistance in GIST. |
| Pubmed ID | 31166382 |
| Year | 2019 |
| Title | Downregulation of lncRNA CCDC26 Contributes to Imatinib Resistance in Human Gastrointestinal Stromal Tumors Through IGF-1R Upregulation |
External Links
| Links for CCDC26 | GenBank HGNC NONCODE |
| Links for gastrointestinal stromal tumor | OMIM COSMIC |