Basic Information
| LncRNA/CircRNA Name | CCHE1 |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_131782 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot |
| Sample | gastric cancer tissues, cell lines (SGC-7901, BGC-823, MGC-803, MKN-45) |
| Expression Pattern | up-regulated |
| Function Description | Expression of lncRNA CCHE1 in the tumor cell lines was increased (p<0.05). Up-regulated lncRNA CCHE1 increased proliferative activity and colony formation capacity. However, down-regulated lncRNA CCHE1 decreased proliferative activity and colony formation capacity. Bcl-2 protein expression increased, but Bax protein expression decreased in lncRNA CCHE1 upregulation group (p<0.05); the effect was reversed in lncRNA CCHE1 down-regulation group (p<0.05). lncRNA CCHE1 may promote the proliferation of gastric cancer cells and inhibit cell apoptosis. |
| Pubmed ID | 29771412 |
| Year | 2018 |
| Title | LncRNA CCHE1 in the Proliferation and Apoptosis of Gastric Cancer Cells |
External Links
| Links for CCHE1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |