Basic Information
| LncRNA/CircRNA Name | CCHE1 |
| Synonyms | CCEPR, CCHE1, lncRNA-CCHE1 |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_131782 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon adenocarcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, other |
| Sample | colon adenocarcinoma cell lines (Hs 698.T, SNU-C1), blood |
| Expression Pattern | up-regulated |
| Function Description | The plasma expression levels of CCHE1 and IL-17A were positively associated with the primary tumor diameter. A significant correlation as demonstrated between the serum levels of CCHE1 and IL-17A in patients with colon adenocarcinoma, but not in the healthy controls. CCHE1 and IL-17A overexpression promoted colon adenocarcinoma cell proliferation. Transfection of small interfering RNA against IL-17A partially reversed the effects of CCHE1 overexpression on cancer cell proliferation. Upregulation of IL-17A was observed after CCHE1 overexpression, while IL-17A overexpression did not significantly change the expression level of CCHE1. |
| Pubmed ID | 31423215 |
| Year | 2019 |
| Title | Cervical Carcinoma High-Expressed Long Non-Coding RNA 1 May Promote Growth of Colon Adenocarcinoma Through interleukin-17A |
External Links
| Links for CCHE1 | GenBank HGNC NONCODE |
| Links for colon adenocarcinoma | OMIM COSMIC |