Basic Information
| LncRNA/CircRNA Name | CDKN2B-AS1 |
| Synonyms | NA |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blot analysis, RIP, Luciferase reporter analysis |
| Sample | OS tissues,osteoblast (hFOB) and OS cells (U2OS, Saos-2, MG-63, and SW1353) |
| Expression Pattern | up-regulated |
| Function Description | CDKN2B-AS1 expression were remarkably upregulated in OS tissues and cells. Moreover, CDKN2B-AS1 knockdown suppressed cell proliferation, migration, and EMT progress in OS.MAP3K3 was negatively regulated by miR-4458 and positively regulated by CDKN2B-AS1. |
| Pubmed ID | 31950433 |
| Year | 2020 |
| Title | Long Non-Coding RNA CDKN2B-AS1 Promotes Osteosarcoma by Increasing the Expression of MAP3K3 via Sponging miR-4458 |
External Links
| Links for CDKN2B-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |