Basic Information
| LncRNA/CircRNA Name | CEBPA-AS1 |
| Synonyms | NA |
| Region | GRCh38_19:33302857-33305054 |
| Ensemble | ENSG00000267296 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blot |
| Sample | OS tissues,cell lines |
| Expression Pattern | down-regulated |
| Function Description | LncRNA CEBPA-AS1 overexpression or NCOR2 elevation inhibited cell proliferation and migration, and ALP and BGP activity, while enhancing apoptosis and tumor formation. lncRNA CEBPA-AS1 overexpression inhibits OS progression through diminishing activation of the Notch signaling pathway via upregulating NCOR2. |
| Pubmed ID | 32160715 |
| Year | 2019 |
| Title | Long Noncoding RNA CEBPA-AS1 Overexpression Inhibits Proliferation and Migration and Stimulates Apoptosis of Osteosarcoma Cells via the Notch Signaling Pathway by MicroRNA-10b-5p-Mediated NCOR2 |
External Links
| Links for CEBPA-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |