Basic Information
| LncRNA/CircRNA Name | CNALPTC1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | Microarray, qRT-PCR, Western blot, Luciferase reporter assay, RIP |
| Sample | PTC tissues, PTC cell lines (TPC-1 and IHH-4) |
| Expression Pattern | up-regulated |
| Function Description | The genomic copy number of CNALPTC1 is amplified and CNALPTC1 expression level is up-regulated in PTC.CNALPTC1 physically associates to miR-30 family and down-regulates miR-30 expression. Furthermore, CNALPTC1 up-regulates the expression of miR-30 targets, such as BCL9, SNAI1, and VIM. The mutation of miR-30 binding site on CNALPTC1 or overexpression of miR-30 abrogates the oncogenic roles of CNALPTC1 in PTC. |
| Pubmed ID | 29416932 |
| Year | 2018 |
| Title | Long noncoding RNA CNALPTC1 promotes cell proliferation and migration of papillary thyroid cancer via sponging miR-30 family. |
External Links
| Links for CNALPTC1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |