Basic Information
| LncRNA/CircRNA Name | CRCAL-4 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RNA-seq, RT-PCR, in vitro knockdown |
| Sample | colorectal tissues, Colon cancer cell lines (HCT116 and SW620) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of CRCAL-3 and CRCAL-4 in colon cancer cells reduced cell viability and colony formation ability, and induced cell cycle arrest. TCGA dataset supported the associations of CRCAL-3 and CRCAL-4 with cell cycle and revealed a co-expression network comprising dysregulated lncRNAs associated with protein-coding genes. |
| Pubmed ID | 29330370 |
| Year | 2018 |
| Title | A RNA-Sequencing approach for the identification of novel long non-coding RNA biomarkers in colorectal cancer. |
External Links
| Links for CRCAL-4 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |