Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | NA |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | medulloblastoma |
| ICD-0-3 | NA |
| Methods | RT-PCR, RIP |
| Sample | medulloblastoma tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | The transcript levels of lncRNA CRNDE were significantly higher in cisplatin treated tumor cells with higher IC50 values. CRNDE acts as a critical mediator of proliferation, apoptosis, migration, invasion and resistance to chemotherapeutics via binding to and negatively regulating miR-29c-3p in medulloblastoma cells. |
| Pubmed ID | 31753063 |
| Year | 2019 |
| Title | Inhibition of Long Non-Coding RNA CRNDE Increases Chemosensitivity of Medulloblastoma Cells by Targeting miR-29c-3p |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for medulloblastoma | OMIM COSMIC |