Basic Information
| LncRNA/CircRNA Name | ADAMTS9-AS2 |
| Synonyms | lncADAMTS9-AS2 |
| Region | GRCh38_3:64684909-65011468 |
| Ensemble | ENSG00000241684 |
| Refseq | NR_038264 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin, 5-Fu | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | ccRCC cell lines (786-O, caki-1 and 769-P), normal renal proximal tubular epithelial cell lines (HKC, HK-2), ccRCC tissues, paired normal adjacent tissues |
| Expression Pattern | down-regulated |
| Function Description | Both overexpressed ADAMTS9-AS2 and underexpressed miR-27a-3p in ccRCC cell lines led to the inhibition of cell proliferation and the reduction of chemoresistance. Additionally, Forkhead Box Protein O1 (FOXO1) was confirmed as the inhibitory target of miR-27a-3p. Induced by ADAMTS9-AS2 overexpression, cell proliferation and chemoresistance exhibited an obvious reduction, FOXO1 expression showed an evident increase, but all were reversed after miR-27a-3p was simultaneously overexpressed. |
| Pubmed ID | 31400752 |
| Year | 2019 |
| Title | LncRNA ADAMTS9-AS2 inhibits cell proliferation and decreases chemoresistance in clear cell renal cell carcinoma via the miR-27a-3p/FOXO1 axis |
External Links
| Links for ADAMTS9-AS2 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |