Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | NA |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Hepatocellular Carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blot analysis etc. |
| Sample | HCC tissues and paired adjacent normal tissues, human liver cell line (HL7702) and liver cancer cell lines(MHCC97H, HCCLM6, SNU-398, and Huh7) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA CRNDE downregulation significantly suppressed cell proliferation and migration. Mechanistic investigations demonstrated that lncRNA CRNDE interacted with miR-337-3p and decreased its expression, thereby increasing the protein expression of miR-337-3p's target, SIX1. In addition, in vivo experiments using a xenograft tumor mouse model revealed that lncRNA CRNDE served as an oncogene, partly through sponging miR-337-3p and upregulating SIX1 in HCC. |
| Pubmed ID | 31099050 |
| Year | 2019 |
| Title | LncRNA CRNDE Promotes Hepatocellular Carcinoma Progression by Upregulating SIX1 Through Modulating miR-337-3p |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for Hepatocellular Carcinoma | OMIM COSMIC |