Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | NA |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | Human cervical cancer cell lines, including SiHa, HeLa, CaSki, Ms751, C33a and c4-1), and human normal cervical epithelial cell line Ect1/E6E7, cervical cancer tissues and adjacent non-cancerous tissues |
| Expression Pattern | up-regulated |
| Function Description | CRNDE expression was increased in cervical cancer tissues and several cervical cancer cell lines. Through loss-of-function and gain-of-function approaches, we found that CRNDE knockdown markedly reduced cervical cancer cell proliferation, while CRNDE overexpression significantly promoted cervical cancer cell growth. Consistently, CRNDE decreasing obviously inhibited tumorigenicity of cervical cancer cells in vivo, whereas CRNDE increasing markedly promoted cervical cancer progression. Mechanistically, we verified that CRNDE bond to p53 upregulated modulator of apoptosis (PUMA), and PUMA was required for CRNDE to enhance cervical cancer cell growth |
| Pubmed ID | 31202167 |
| Year | 2019 |
| Title | Long non-coding RNA CRNDE enhances cervical cancer progression by suppressing PUMA expression |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |